Coronary artery disease (CAD)

Mostly we see in young people , genetic agent called lipoprotein.

Coronary artery disease is the narrowing or blockage of the coronary arteries, usually caused by atherosclerosis. Atherosclerosis (sometimes called “hardening” or “clogging” of the arteries) is the buildup of cholesterol and fatty deposits (called plaques) on the inner walls of the arteries.

                      Or
Coronary artery disease is a types of blood vessel disorder that is included in the general category of atherosclerosis .in this disorder there is formation hard fatty streak and deposited inside the vessel wall

Causes-

.obesity
. Hypertension
. secondary life style
.stress
. hypertension, infection,any cardiac disese
. diabetes
.excess of cholesterol(fat intake consumption  of oily &spicy food)
. sitting at one place
.lack of physical activity
.lesser intake of fruits and vegetables
.high blood glucose (sugar)–(leads to type2 diabetes
.low level of (LDL) cholesterol
.high level of triglycerides
. large waist circumference

Pathological changes —

.it is characterized by a focal deposit of cholestols,lipids and blood cells, primary with in the optimal well of the artery.

.the plaque formation is the result of complex interactions between the components of the blood & it’s elements forming the vascular wall.

.due to plaque formation ,a nonspecific marker of inflammation  i.e. C-reactive protein (cpr) increase which mediates inflammation and trigger the rupture of plaque & promote the oxidation of LDL cholesterol. That leads to increased  uptake of macrophages in the endothelial lining.

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