Must be given orally for pseudomembranous colitis with Clostridium difficile infection as works in bowel lumen
Useful against anaerobic bacteria and some protozoal infections
Broken into toxic compounds which effect bacterial metabolism
Anaerobic bacteria including Bacteroides fragilis
Trichomonas, Entamoeba histolytica, Clostridium Tetanus
Disulfiram effect with alcohol – flushing, abdominal pain, hypotension
Reduced Warfarin breakdown – ↑ INR
lithium and phenytoin toxicity, porphyria.
Prolonged courses cause peripheral neuropathy.
Pregnancy and breastfeeding,Porphyria
Take advice in Pregnancy and breastfeeding,Porphyria
Nausea, vomiting,diarrhoea, metallic taste, hepatitis
Headache, Sensory neuropathy with prolonged usage > 4 weeks
Seizures following high doses
Dose range:- Described in above attached photo..(may vary according to patients)